摘要 II
Abstract III
目次 IV
圖目次 VII
表目次 IX
附錄目次 X
縮寫表 XI
1. 前言 1
2. 文獻回顧 3
2.1. 骨關節炎 3
2.2. 水凝膠 3
2.2.1. 互穿聚合物網絡水凝膠 4
2.2.2. 可注射水凝膠 4
2.2.3. 智能水凝膠 4
2.3. 水凝膠交聯方式 4
2.3.1. 物理性交聯 4
2.3.2. 化學性交聯 5
2.4. 水凝膠應用 5
2.4.1. 傷口敷料 5
2.4.2. 組織工程 6
2.4.3. 藥物緩釋系統 6
2.5. 羧甲基幾丁聚醣 6
2.6. 透明質酸 7
2.7. 酪胺修飾 7
2.8. 交聯劑 8
2.8.1. 戊二醛 8
2.8.2. 梔子素 8
2.8.3. 過氧化鈣 8
2.9. 交聯酵素 8
2.9.1. 漆酶 8
2.9.2. 酪胺酸酶 9
2.9.3. 辣根過氧化酶 9
2.9.4. 轉麩醯胺酸酶 9
2.10. 多酚類 10
2.10.1. 單寧酸 10
2.10.2. 沒食子酸 10
2.11. 黃連素 10
3. 材料與儀器 12
3.1. 實驗藥品 12
3.2. 儀器設備 13
4. 實驗架構 14
5. 實驗方法 15
5.1. 酪胺修飾羧甲基幾丁聚醣及透明質酸 15
5.2. FTIR 15
5.3. 1H NMR 15
5.4. 水凝膠之製備 15
5.5. 凝膠時間觀察 15
5.6. 紫外-可見光光譜分析 16
5.7. SEM 16
5.8. 壓縮試驗 16
5.9. 流變性質分析 16
5.10. 膨潤度分析 16
5.11. 降解試驗 17
5.12. 包覆黃連素 17
5.12.1. 體外藥物釋放試驗 17
5.12.2. 酵素降解之藥物釋放 17
5.13. DPPH自由基清除能力 18
5.14. 統計分析 18
6. 結果 19
6.1. 酪胺修飾聚合物材料分析 19
6.1.1. FTIR分析結果 19
6.1.2. 1H NMR分析結果 19
6.2. 水凝膠分析 20
6.2.1. 水凝膠凝膠時間 20
6.2.2. 水凝膠外觀觀察 20
6.2.3. 紫外-可見光分析 20
6.2.4. FTIR分析結果 20
6.2.5. 水凝膠之SEM 21
6.3. 水凝膠物理機械性質分析 21
6.3.1. 壓縮試驗結果 21
6.3.2. 流變分析結果 22
6.3.3. 膨潤試驗結果 22
6.3.4. 降解試驗結果 23
6.4. 包覆黃連素 23
6.4.1. FTIR分析結果 23
6.4.2. 水凝膠包覆BBR之SEM 24
6.4.3. 體外藥物累積釋放試驗 24
6.5. 抗氧化特性分析 25
6.5.1. DPPH自由基清除能力 25
7. 結論 26
參考文獻 27
圖 34
表 52
附錄 54

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